Wednesday’s series showdown will be broadcast locally on MARQ (Cubs feed) and NBCS-PH+ (Phillies feed). First pitch is scheduled for 7:40 PM ET. Fans can stream the game in high definition on Fubo, which offers access to regional sports networks and national MLB coverage.

The Philadelphia Phillies (8-15) continue their road trip at Wrigley Field this Wednesday, April 22, facing the Chicago Cubs (14-9). The Phillies are looking to climb out of an early-season hole, currently sitting seven games under .500 and searching for rotation stability. The Cubs, meanwhile, have been one of the NL Central's most consistent teams, backed by a potent lineup and a pitching staff that has performed well despite several injuries.

Chicago’s offense is firing on all cylinders, led by Nico Hoerner, who is batting .325 with 21 RBIs. He is joined by Alex Bregman and Ian Happ, providing a veteran core that has been difficult for opposing pitchers to navigate. For Philadelphia, Bryce Harper and Trea Turner remain the primary threats, though the team has struggled to find consistent run support for their starters. Catch every inning live on Fubo.

The pitching duel features a notable return to the mound. The Cubs turn to Matthew Boyd (LHP), who is expected to be activated from the IL to make this start. Boyd showed promise in his rehab outings and looks to improve on his 1-1 record. He faces Phillies right-hander Kyle Backhus (0-0), who enters with a 5.40 ERA and a 1.20 WHIP in limited action. You can witness this National League battle streaming live on Fubo.

The key storyline for the Phillies is their desperate need for a "stopper" performance on the mound to snap out of their road funk. For the Cubs, the focus is on the health and efficiency of their rotation; with Justin Steele and others sidelined, Boyd’s return is a welcome boost. Fubo is your home for the complete broadcast.

Phillies vs. Cubs Betting Odds & Predictions

The Cubs enter the game as significant home favorites. Oddsmakers are banking on Chicago's superior record and the Phillies' historical struggles when trailing late to favor the home team.

Prediction: Matthew Boyd’s return provides an emotional and statistical lift for Chicago. While the Phillies have the power to keep it close, the Cubs' bullpen and home field advantage should prove to be the difference. Final Score: Cubs 6, Phillies 3.

Individual Matchups: Stars and Playmakers

The marquee matchup features the elite power of Bryce Harper against the deceptive southpaw delivery of Matthew Boyd. Harper’s ability to handle left-handed breaking balls will be a major factor early in the game.

Philadelphia relies on the leadership of Bryce Harper and the speed of Trea Turner to spark an offense that ranks among the league leaders in extra-base hits but has struggled with consistency.

Stream the MLB on Fubo

Fubo is the essential destination for baseball fans. Catch regional sports networks like MARQ and NBCS-PH+, national broadcasts, and premier matchups with the most flexible streaming plans available, ensuring you never miss a highlight from the Phillies or Cubs.

Fubo: New subscribers can check out current promotions to ensure they have access to local and national MLB coverage for the season. Follow the Cubs as they aim for another NL Central title.

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