Wednesday’s series showdown will be broadcast locally on Dbacks.TV (Arizona feed) and Chicago Sports Network (CHSN) (White Sox feed). First pitch is scheduled for 9:40 PM ET. Fans can stream the game in high definition on Fubo, which offers access to regional sports networks and national MLB coverage.

The Arizona Diamondbacks (13-10) look to get back into the win column this Wednesday, April 22, as they host the Chicago White Sox (9-14) for the second game of a three-game set. The White Sox took the series opener in emphatic fashion with an 11-5 victory on Tuesday, fueled by a multi-home run attack. Arizona will need to tighten up its defense and find early run support to prevent the South Siders from clinching the series tonight.

Arizona’s offense is led by Corbin Carroll, who recently returned to action and provides elite speed at the top of the order. Veteran Ildemaro Vargas is also coming off a productive Tuesday where he launched a home run and drove in three. The White Sox counter with an offense that leads the league in surprise power outbursts, looking for continued production from their middle-of-the-order bats. Catch every inning live on Fubo.

The pitching duel features a battle of southpaws. Arizona turns to Eduardo Rodriguez (1-0), who has been a pillar of the rotation with a sparkling 1.96 ERA through his first few starts of 2026. He faces off against Chicago’s Anthony Kay (1-0), who carries a steady 2.60 ERA and looks to build on his momentum. You can witness this interleague battle streaming live on Fubo.

The defining storyline for the Diamondbacks is whether Rodriguez can silence a White Sox lineup that thrived on Tuesday. For Chicago, the challenge is maintaining offensive consistency against an elite starter. With Arizona currently third in the NL West, every home game is vital for keeping pace in a crowded divisional race. Fubo is your home for the complete broadcast.

White Sox vs. Diamondbacks Betting Odds & Predictions

The Diamondbacks enter the game as home favorites. Oddsmakers are banking on Eduardo Rodriguez's superior ERA and Arizona's 17-6-0 record against the spread this season to favor the snakes.

Prediction: Eduardo Rodriguez has been nearly unhittable to start the year. While the White Sox offense erupted on Tuesday, repeating that performance against a pitcher of Rodriguez's caliber is a tall task. Final Score: Diamondbacks 5, White Sox 3.

Individual Matchups: Stars and Playmakers

The marquee matchup features the elite speed of Corbin Carroll against the veteran composure of Anthony Kay. Carroll’s ability to create chaos on the basepaths will be a major factor early in the game.

*Season stats current through April 22.

Chicago relies on a balanced attack, aiming to replicate the 11-run production from Tuesday night to pressure Arizona's bullpen.

Stream the MLB on Fubo

Fubo is the essential destination for baseball fans. Catch regional sports networks like Dbacks.TV and CHSN, national broadcasts, and premier matchups with the most flexible streaming plans available, ensuring you never miss a highlight from the White Sox or Diamondbacks.

Fubo: New subscribers can check out current promotions to ensure they have access to local and national MLB coverage for the season. Follow the Diamondbacks as they aim for another deep NL postseason run.

Frequently Asked Questions