Wednesday’s series opener will be broadcast locally on Detroit SportsNet (DSN) and Brewers.TV. First pitch is scheduled for 6:40 PM ET. Fans can stream the game in high definition on Fubo, which offers access to regional sports networks and national MLB coverage.

The Milwaukee Brewers (13-9) visit the Detroit Tigers (12-12) this Wednesday, April 22, to continue an intriguing interleague series at Comerica Park. Milwaukee enters as one of the highest-scoring teams in the National League, despite a flurry of early-season injuries to their core stars. The Tigers, playing at .500, look to stabilize their home stand and climb the AL Central rankings behind a resurgent pitching staff.

The Brewers have found unlikely heroes in Jake Bauers and Gary Sanchez, both of whom have provided massive power numbers while Christian Yelich and Jackson Chourio remain on the injured list. Detroit relies on the elite on-base skills of Kevin McGonigle and the burgeoning power of Dillon Dingler. Catch every pitch and home run live on Fubo.

The pitching duel features a veteran right-hander against a rising arm with eye-popping numbers. Detroit turns to Casey Mize (1-1, 2.78 ERA), who has demonstrated sharp command and high strikeout potential early in 2026. He faces Milwaukee's Chad Patrick (1-0, 0.95 ERA). While Patrick’s ERA is elite, analysts suggest he may be due for regression given a low strikeout rate and a high strand rate. You can witness this interleague clash streaming live on Fubo.

The defining storyline for the Brewers is their ability to "weather the storm" while missing three of their top bats. For Detroit, the focus is on Mize’s ability to silence a Milwaukee lineup that is prone to high-scoring outbursts. Fubo is your home for the complete broadcast.

Brewers vs. Tigers Betting Odds & Predictions

The Tigers enter the matchup as home favorites. Oddsmakers are banking on Casey Mize’s experience and the potential for the Brewers' "patchwork" lineup to struggle away from Milwaukee.

Prediction: Casey Mize has the edge in experience and secondary stuff. While Patrick has been a great story, the Tigers' disciplined approach should eventually get to him. Final Score: Tigers 4, Brewers 2.

Individual Matchups: Stars and Playmakers

The marquee matchup features the elite power of Gary Sanchez against the precision of Casey Mize. Sanchez has already launched five home runs in limited plate appearances this season.

*Season stats.

Detroit relies on the bat of Kevin McGonigle and the run-producing ability of Dillon Dingler to anchor their offense at Comerica Park.

Stream the MLB on Fubo

Fubo is the essential destination for baseball fans. Catch regional sports networks like DSN and Brewers.TV, national broadcasts, and premier matchups with the most flexible streaming plans available, ensuring you never miss a highlight from the Brewers or Tigers.

Fubo: New subscribers can check out current promotions to ensure they have access to local and national MLB coverage for the season. Follow the Brewers as they aim to reclaim the NL Central lead.

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