MLBPA player leaders agreed unanimously not to accept MLB's final proposal, and there was no deal on a new collective bargaining agreement before MLB's 5 p.m. ET deadline.

MLB had threatened to cancel its March 31 Opening Day without a new deal, and commissioner Rob Manfred confirmed that Tuesday afternoon.

"The calendar dictates that we're not going to be able to play the first two series of the regular season and those games are officially canceled," Manfred said.

The sides will head home after negotiating for nine days and determine next steps for returning to the bargaining table.