Baseball players suspended during the season for a PED violation will not be eligible for that year's postseason under changes to the sport's drug agreement announced Friday.

In the most significant toughening to the drug rules in eight years, Major League Baseball and the Major League Baseball Players Association said the penalty will increase from 50 games to 80 for a first testing violation and from 100 games to a season-long 162 for a second. A third violation remains a lifetime ban.