Giancarlo Stanton reached a career milestone Tuesday night, hitting his 400th home run as the New York Yankees defeated the Detroit Tigers 5-1.

Stanton's two-run homer off reliever Jose Cisnero broke a 1-all tie in the sixth inning. The slugger reached 400 homers in 1,520 career games -- fourth fastest in major league history, behind Mark McGwire (1,412), Babe Ruth (1,475) and Alex Rodriguez (1,489). Albert Pujols is fifth at 1,523.