Albert Pujols hit the 694th home run of his career on Monday night in Cincinnati.

The home run came against a 450th different pitcher, a Major League record.

Reds reliever Ross Detwiler gave up a 369-foot, two-run homer to right field in the third inning of the St. Louis Cardinals' 13-4 win.

"Obviously, his career speaks for itself," Detwiler said. "All of his numbers are better than anything I've seen in person. It is kind of unbelievable. He's been so good for so long.

"I got ahead of him. I tried to go high fastball. I didn't get it high enough, and it leaked over the plate a little bit more than I wanted it to. The ball jumps off his bat."

Pujols is now just two home runs shy of tying Alex Rodriguez for fourth on the all-time list (696).