Michael Brantley left Sunday's win over the Kansas City Royals in the fourth inning with a sprained right ankle.
Brandon Guyer moved to left field to replace Brantley for the start of the bottom of the fourth inning. Lonnie Chisenhall replaced Guyer in right field.
He appeared in just 11 games last season because of a shoulder injury.
Brantley, who was 0-for-2 Sunday before exiting, is hitting .283 with five home runs and 17 RBIs this season in 26 games.