The Rays entered the ninth inning of Friday's game against the White Sox trailing 7-4, but they scored five runs in the final inning en route to their first win of 2011.
Tampa Bay's Dan Johnson hit a three-run homer to cap the rally.
"No feeling like it. It makes everything better," Johnson said. "We were just talking about how the food tastes so much better. [Losing] leaves such a bad taste in your mouth. Everything seems better right now."
The Rays had scored a total of eight runs in their first six games before exploding for nine against Chicago.
Rays Rally For First Win Of Season