Cleveland Guardians star third baseman Jose Ramirez fractured his left hamate bone on a swing Saturday and will be sidelined indefinitely, a major setback for the two-time defending AL Central champions.

Ramirez was injured leading off the fifth inning of Cleveland's 3-1 win over the Detroit Tigers. Manager Stephen Vogt confirmed the break after the game, following imaging tests on the 33-year-old.

"He had a similar injury I think to his right hand a few years ago," said Vogt. "He tried to go back out. He knew the position we were in, grabbed his glove and said 'Maybe I can still play defense,' but he couldn't squeeze his glove. Hosey wanted to get back out there to help us win that game. He just couldn't."

Ramirez, a seven-time All-Star and the face of the Guardians' franchise, previously fractured his right hamate bone in 2019, the only other injured list stint of his career. He missed roughly one month following surgery after an initial timeline of up to seven weeks.

The switch-hitter entered Saturday batting .238 with 10 home runs and 33 RBIs this season. A career .274 hitter, Ramirez has finished in the top four of MVP voting five times and holds numerous franchise records.

Cleveland also lost outfielders Chase DeLauter and Angel Martinez to injuries in the first two innings. DeLauter suffered a bruised right rib cage colliding with the outfield wall, while Martinez sustained a foot bruise after fouling a ball off it.

With Ramirez out, Vogt shifted Rhys Hoskins from first base to left field, a position the veteran had not played since 2018 with the Philadelphia Phillies.

"We're working through the logistics and what the next steps are so we'll know more tomorrow or the next day," said Vogt. "These things can get complicated."

It remains unclear whether DeLauter and Martinez will also require injured list placements.

The Guardians are in first place in the AL Central with a 39-33 record.