Monday’s series opener will be broadcast locally on Space City Home Network (Astros feed) and Bally Sports Great Lakes (Guardians feed). First pitch is scheduled for 6:10 PM ET. Fans can stream the game in high definition on Fubo, which offers access to regional sports networks and national MLB coverage.

The Houston Astros (8-15) head into Progressive Field this Monday, April 20, in desperate need of a spark. Houston has struggled significantly away from home early in 2026, carrying a brutal eight-game road losing streak into this three-game set. They face a Cleveland Guardians (13-10) squad that currently sits atop the AL Central and has looked comfortable at home with a 7-3 record.

Houston’s offense is looking to bounce back behind Yordan Alvarez, who has been a bright spot with six home runs in his last 10 games. However, injuries have ravaged the Astros' depth, with Jeremy Peña and Joey Loperfido recently landing on the IL. Cleveland counters with a disciplined lineup led by perennial All-Star José Ramírez, who leads the team with six home runs and remains one of the toughest outs in the league. Catch every pitch live on Fubo.

The individual matchups center on a battle of young right-handers. Houston turns to Spencer Arrighetti (1-0), who has been a revelation with a 1.50 ERA and 1.17 WHIP. He faces Cleveland’s Slade Cecconi (0-2), who is searching for his first win of the season despite a high 5.03 ERA. You can witness this American League clash streaming live on Fubo.

The defining storyline for Houston is whether they can find rotation stability while stars like Cristian Javier and Hunter Brown recover from shoulder strains. For the Guardians, maintaining their efficiency with runners in scoring position will be key, as they are 10-4 when recording at least eight hits. Fubo is your home for the complete broadcast.

Astros vs. Guardians Betting Odds & Predictions

The Guardians enter the opener as slight favorites at home. While Arrighetti has been the better pitcher statistically, Houston’s struggles on the road have oddsmakers leaning toward Cleveland.

Prediction: Spencer Arrighetti gives Houston a real chance to snap the skid, but Cleveland’s bullpen remains one of the best in the AL. Expect a tight contest that hinges on late-inning execution. Final Score: Guardians 5, Astros 4.

Individual Matchups: Stars and Playmakers

The marquee matchup features the elite power of Yordan Alvarez against the high-velocity arsenal of Slade Cecconi. Alvarez has been scorching lately, leading the Astros in multiple offensive categories.

Cleveland relies on the power of José Ramírez and the recent emergence of Angel Martinez, who is batting .350 over his last 10 outings.

Stream the MLB on Fubo

Fubo is the essential destination for baseball fans. Catch regional sports networks like Space City Home Network and BSGL, national broadcasts, and premier matchups with the most flexible streaming plans available, ensuring you never miss a highlight from the Astros or Guardians.

Fubo: New subscribers can check out current promotions to ensure they have access to local and national MLB coverage for the season. Follow the Astros as they seek to navigate early-season hurdles.

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