Monday’s series opener will be broadcast locally on Cardinals.TV (Cardinals feed) and Guardians.TV (Guardians feed), with additional streaming on ESPN+ and MLB.TV. First pitch is scheduled for 7:45 PM ET. Fans can stream the game in high definition on Fubo, which offers access to regional sports networks and national MLB coverage.

The Cleveland Guardians (9-7) head to St. Louis this Monday night to begin a three-game interleague set against the St. Louis Cardinals (8-7). Both teams are looking to shake off recent skids; Cleveland dropped a high-scoring affair to the Braves yesterday, while St. Louis is currently on a two-game losing streak. Despite the recent bumps, both clubs remain firmly in the mix in their respective divisions early in the 2026 campaign.

Cleveland's offense has found a reliable anchor in rookie Chase DeLauter, who is hitting .300 with four doubles and looks like the team's most dangerous bat. They’ll be tested by the Cardinals' power-heavy middle of the order, where Jordan Walker has been on a tear, launching six home runs over his last 10 games. Catch every pitch and home run live on Fubo.

The pitching matchup features a battle of young arms. The Guardians turn to Gavin Williams (RHP), who has been stellar with a 2.04 ERA and 25 strikeouts in his first 17.2 innings. He faces St. Louis southpaw Matthew Liberatore (LHP), who holds a 3.38 ERA and is looking to secure his first win of the season. You can witness this interleague clash streaming live on Fubo.

The defining storyline for Cleveland will be their bullpen management, as they look to return Hunter Gaddis to the active roster soon. For St. Louis, all eyes are on the health of Masyn Winn, who is currently day-to-day. If the Cardinals' defense can back up Liberatore's pitch-to-contact style, they have a strong chance of holding off the Guardians' aggressive base-running. Fubo is your home for the complete broadcast.

Guardians vs. Cardinals Betting Odds & Predictions

The Guardians enter the series opener as slight road favorites. Oddsmakers are backing Gavin Williams' elite early-season form, though the Cardinals' home-field advantage makes this a very tight line.

Prediction: Gavin Williams has shown the swing-and-miss stuff necessary to navigate the Cardinals' power hitters. While Jordan Walker is dangerous, Cleveland's offense has shown better depth recently. Final Score: Guardians 5, Cardinals 3.

Individual Matchups: Stars and Playmakers

The marquee matchup features the elite power of Jordan Walker against the high-octane fastball of Gavin Williams. Walker's ability to drive the ball to the gaps will be the key to the Cardinals' offense.

St. Louis relies on Jordan Walker and the contact hitting of Alec Burleson to pressure opposing rotations and support their pitching staff.

Stream the MLB on Fubo

Fubo is the essential destination for baseball fans. Catch regional sports networks like Guardians.TV and Cardinals.TV, national broadcasts, and premier matchups with the most flexible streaming plans available, ensuring you never miss a highlight from the Guardians or Cardinals.

Fubo: New subscribers can check out current promotions to ensure they have access to local and national MLB coverage for the season. Follow the Guardians as they aim to conquer the AL Central.

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