The Astros lost 100 games in a season for the first time in franchise history, falling to Rodrigo Lopez and the Cubs 2-1 Saturday.
The Astros, who began play in 1962 as the Colt .45s, dropped to 51-100.
Colorado and the Angels are the only remaining franchises that have never lost 100 games in a season.
Astros Lose 100 Games For First Time