Mat Latos is now sidelined with a sore right shoulder.
San Diego manager Bud Black told reporters Friday morning that Latos will not make a scheduled start on Saturday.
Latos is believed to be the front-runner to start for the team on Opening Day.
"He's a little sore ... it just sort of popped up," Black said.
Latos, who won 14 games a year ago in his first full Major League season, has allowed 10 earned runs in 10 innings over four Cactus League starts.
Latos To Miss Start With Sore Shoulder