Mariners right-hander Doug Fister will miss his scheduled start Saturday against the Angels with tightness and fatigue in his shoulder. Fister has the second-best ERA in the American League. Seattle manager Don Wakamatsu said Friday that Fister's velocity was down Monday when he allowed five runs in seven innings in a loss to the Twins. Fister is 3-3 with a 2.45 ERA this season. He is on pace to throw almost 240 innings.