Hector Santiago's 10-game suspension for having a foreign substance on his glove has been upheld after an appeal, according to sources.

Santiago is the first and only pitcher so far to be ejected and subsequently suspended after Major League Baseball's crackdown on pitchers using sticky substances on baseballs.

The Mariners will not be able to fill Santiago's roster spot for the entirety of his 10-game suspension, per MLB's rules on pitchers using foreign substances.