The United States defeated the World team 7-6 in Sunday's All-Star Futures Game at Marlins Park.
Honeywell, who was the only pitcher to throw more than one inning, struck out four in two scoreless frames. He was the first of 10 pitchers for the United States, and the group combined for 11 strikeouts.
He threw a screwball to Alex Verdugo of the Los Angeles Dodgers in the first inning.
"I had thrown him everything else," said Honeywell, a right-hander who is with Triple-A Durham. "I thought, `If I'm going to do it, I'm going to do it right here.' And it was a really good one."