Aaron Judge might be headed back to the injured list just a few days after the New York Yankees activated him.

Judge appeared to re-injure his right leg running to second base on Wednesday night. Two innings after that, Judge was lifted for a defensive replacement. The Yankees had just removed Judge from the IL on Tuesday.

"He tightened up again in that calf area running to second base, so we'll see where he's at," Aaron Boone said. "Doesn't seem to be overly serious but enough that we needed to get him out of there. [It's] frustrating, no question. Obviously, he's very frustrated, but we'll see where we're at as we get through it tonight and where he's at feeling tomorrow."

Boone said that it's "possible" Judge could be headed for another IL stint, but added, "I think we'll have a better feel later tonight and into tomorrow exactly where he's at."