The Houston Astros lost as historic favorites with Justin Verlander pitching on Wednesday, leading to a favorable night for sportsbooks.

Despite closing as +435 underdogs at Caesars Sportsbook and managing only two hits off Verlander in their 2-1 victory, the visiting Detroit Tigers pulled off the largest upset in the Major Leagues over the past 15 years, according to a sports betting database.

Just 10 days ago, the Astros were -460 road favorites over the Baltimore Orioles (+390). Houston lost that game 8-7, in what prior to Wednesday was the largest upset since the Washington Nationals beat the Minnesota Twins as +395 underdogs in 2007.