Ervin Santana has been suspended 80 games without pay for testing positive for stanozolol, a performance-enhancing substance. The suspension is effective for the first 80 games of the regular season.

Santana said he did not know how the PED got into his system.

"I preach hard work, and don't believe in short cuts," Santana said. "I am very disappointed that I tested positive for a performance enhancing drug. I am frustrated that I can't pinpoint how the substance in question entered my body. I would never knowingly take anything illegal to enhance my performance."

Mike Pelfrey will be the No. 5 starter to take Santana's spot in the rotation.

"It's disappointing. It's difficult," Twins GM Terry Ryan said. "We had a fairly decent spring. Now we've got to regroup here and hopefully it won't affect us as we move forward."