Boston's Manny Ramirez hit his 400th career home run Sunday, a three-run shot in the fifth inning off Seattle starter Gil Meche during Boston's 5-4 loss to the Mariners. Ramirez is the 39th player in major league history to reach 400 homers, and just the fifth to reach the mark in a Red Sox uniform. The others were Jimmie Foxx, Ted Williams, Carl Yastrzemski and Andre Dawson. Ramirez hit a 1-1 fastball from Meche an estimated 404 feet into the seats in right-center field. It was his 10th homer of the season and second in the three-game series with Seattle. Ramirez is the 13th player to reach the mark before his 33rd birthday and just the fourth since Harmon Killebrew in 1969. He is the fifth-fastest to 400 in number of at-bats, behind Mark McGwire, Babe Ruth, Killebrew and Jim Thome.