Tigers first baseman Miguel Cabrera left Tuesday's game against the White Sox after six innings when he aggravated his sore shoulder.
"It hurts when I swing," he said after the game. "It doesn't feel right."
Tigers manager Jim Leyland said he doubted Cabrera will play Wednesday, but isn't sure on a timetable for his return.
"It's not a concern in the sense that I think it is serious, but I'm concerned because I'm not sure when I'm going to be able to play him," Leyland said. "I'm going to have to watch him closely."
Cabrera Aggravates Shoulder Injury